Both supplements are generally considered safe when used as directed, though some individuals may experience mild gastrointestinal discomfort with berberine. It is crucial to monitor one's response and adjust dosages as necessary.
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While sulfamic acid is relatively less toxic than many other strong acids, safety precautions are still necessary when handling the compound. It can cause irritation to skin, eyes, and respiratory tract. Therefore, personal protective equipment (PPE) such as gloves and goggles should be utilized when working with this chemical. Proper ventilation in workspaces is also essential to minimize inhalation risks.
Headaches and feelings of anxiety may arise for some users, particularly if they are sensitive to the stimulatory effects of PQQ. As PQQ influences energy metabolism, some people might experience increased energy that could potentially lead to feelings of jitteriness or anxiety, especially if consumed in excess or close to bedtime. For those predisposed to anxiety or those with a history of migraines, careful monitoring of dosage is recommended.